No Road Back (1957) was Sean's first major movie role, and it followed by several Tv-movies such as Anna Christie (1957) (TV), Macbeth (1961) (TV) and Anna Karenina (1961) (TV) and guest appearances on TV-series, and also films such as Hell Drivers (1957), Another Time, Another Place (1958), Darby O'Gill and the Little People (1959), The Frightened City (1961). In 1962 he appeared in The Longest Day (1962) with a host of other stars,
His big breakthrough came in 1962 when he starred as secret agent James Bond in Dr. No (1962). He played James Bond in six more films:From Russia with Love (1963), Goldfinger (1964), Thunderball (1965), You Only Live Twice (1967), Diamonds Are Forever (1971), and Never Say Never Again (1983).
After and during the success of the Bond-films he has maintained a successful career as an actor and has appeared in films, including Alfred Hitchcock's masterpiece Marnie (1964), The Hill (1965), Murder on the Orient Express (1974), The Man Who Would Be King (1975), The Wind and the Lion (1975), Razbojniki za vse case (1981), Highlander - Borba nesmrtnikov (1986), Der Name der Rose (1986), The Untouchables(1987) (which earned him an Oscar for best actor in a supporting role), Indiana Jones and the Last Crusade (1989), The Hunt for Red October(1990), Vzhajajoce sonce (1993), Alcatraz (1996), Finding Forrester (2000), and The League of Extraordinary Gentlemen (2003).
Sean married actress Diane Cilento in 1962 and they had a son, Jason Connery, born on January 11, 1963, he followed in his father's footsteps and also became an actor. The marriage ended in divorce in 1973. In 1975 he married Micheline Roquebrune and they have stayed married, they have no children together. He is also a grandfather. His son, Jason and his ex-wife, actress Mia Sara had a son, Dashiell Quinn Connery, in 1997.